Journal article
Exploiting Macromolecular Design to Optimize the Antibacterial Activity of Alkylated Cationic Oligomers
JL Grace, EK Schneider-Futschik, AG Elliott, M Amado, NP Truong, MA Cooper, J Li, TP Davis, JF Quinn, T Velkov, MR Whittaker
Biomacromolecules | AMER CHEMICAL SOC | Published : 2018
Abstract
There is growing interest in synthetic polymers which co-opt the structural features of naturally occurring antimicrobial peptides. However, our understanding of how macromolecular architecture affects antibacterial activity remains limited. To address this, we investigated whether varying architectures of a series of block and statistical co-oligomers influenced antibacterial and hemolytic activity. Cu(0)-mediated polymerization was used to synthesize oligomers constituting 2-(Boc-amino)ethyl acrylate units and either diethylene glycol ethyl ether acrylate (DEGEEA) or poly(ethylene glycol) methyl ether acrylate units with varying macromolecular architecture; subsequent deprotection produced..
View full abstractGrants
Awarded by National Institutes of Health
Funding Acknowledgements
This collaborative research was conducted by the Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology (project number CE140100036). J.L.G. wishes to acknowledge receiving an APA scholarship. T.P.D. wishes to acknowledge the award of an Australian Laureate Fellowship and J.F.Q., a Future Fellowship from the Australian Research Council. J.L. and T.V. are supported by a research grant from the National Institute of Allergy and Infectious Diseases of the National Institutes of Health (RO1 AI111965). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute of Allergy and Infectious Diseases or the National Institutes of Health. J.L. is an Australian NHMRC Senior Research Fellow. T.V. is an Australian NHMRC Industry Career Development Research Fellow. M.A.C. is an Australian NHMRC Principal Research Fellow (APP1059354). We thank Janet C. Reid for conducting cytotoxicity assays. EKSF is an Australian NHMRC Peter Doherty Fellow (APP1157287).